Clinical Trial: Effect of Tonsillectomy on Longterm Renal Outcome of IgA Nephropathy
Study Status: Suspended
Recruit Status: Suspended
Study Type: Interventional
Official Title: Effect of Tonsillectomy on Longterm Renal Outcome of IgA Nephropathy :a Prospective,Randomized,Controlled Study.
Brief Summary: The effect of tonsillectomy therapy on IgA nephropathy is still controversial.Few prospective,randomized investigations have examined how tonsillectomy affects the shortterm and longterm renal outcome of IgA nephropathy.This is A prospective,randomized ,controlled study to explore the longterm effect of tonsillectomy for patients with IgA nephropathy.
Detailed Summary:
Sponsor: Sun Yat-sen University
Current Primary Outcome: Renal survival rate or Deterioration of renal function [ Time Frame: Every 12months for 10 years after tonsillectomy ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Remission of proteinuria (complete or partial) [ Time Frame: every 3-12months for 10 years after tonsillectomy ]The remission rate of proteinuria (include complete or partial remission )
- Remission of hematuria (complete or partial) [ Time Frame: every 3-12months for 10 years after tonsillectomy ]The remission rate of hematuria (include complete or partial remission )
- Repeat renal biopsy [ Time Frame: the fifth and tenth year after tonsillectomy ]reevaluate the renal histological changes by the Lee's glomerular grading
- Side effects [ Time Frame: every 3-12months for 10 years after tonsillectomy ]The shortterm and longterm side effects of tonsillectomy.
Original Secondary Outcome: Same as current
Information By: Sun Yat-sen University
Dates:
Date Received: May 19, 2015
Date Started: March 2011
Date Completion: March 2023
Last Updated: June 10, 2015
Last Verified: June 2015