Clinical Trial: The Prevalence of Sub Clinical Hypothyroidism During Early Pregnancy in Pakistan

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: The Prevalence of Sub Clinical Hypothyroidism During Early Pregnancy in Pakistan

Brief Summary: The Precious study is likely to help determine the frequency (percentage) of subclinical hypothyroidism among pregnant women in Pakistan It will also help to determine the risk factors for developing subclinical hypothyroidism during pregnancy

Detailed Summary:
Sponsor: Abbott

Current Primary Outcome: Frequency of subclinical hypothyroidism in pregnant females [ Time Frame: 12 months ]

Continuous variables with normal and non-normal distributions would be reported as mean (SD) and median [inter-quartile range (IQR)], respectively. Prevalence of subclinical hypothyroidism with 95% confidence Interval (CI) will be calculated. Continuous variables between group will compared by using Independent sample t test, and categorical variables will compare by using the chi-square test.


Original Primary Outcome: Same as current

Current Secondary Outcome: The risk factors that might be associated with subclinical hypothyroidism in all enrolled pregnant patients. [ Time Frame: 12 months ]

Odds Ratios (OR) and their 95% Confidence Intervals (CI) will be estimated using Logistic Regression. The likelihood ratio test used to assess the association between the explanatory variables and the risk of the subclinical hypothyroidism. Univariable analyses will perform to examine the effect of each variable on the risk of subclinical hypothyroidism. In multivariate analysis all insignificant variables (p >0.05) will check for their confounding and interaction effects before their removal from the final model.


Original Secondary Outcome: Same as current

Information By: Abbott

Dates:
Date Received: January 26, 2017
Date Started: January 2017
Date Completion: January 2018
Last Updated: January 26, 2017
Last Verified: January 2017