Clinical Trial: Central Hypothyroidism, a Novel Laboratory Measurement

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Central Hypothyroidism,a New Laboratory Approach for Hormone Measurement

Brief Summary: Medical management of central hypothyroidism is controversial due to lack of reference for evaluation of pituitary negative feedback. Therefore, titration of medical treatment is based on T4 levels, measured with variable laboratory methods. Patients who have central hypothyroidism usually have concomitant deficiencies in other pituitary hormones for which they need replacement therapy such as steroids, testosterone and growth hormone. This combined hormone deficiency makes clinical and laboratory evaluation challenging among these patients. Symptomatically, central hypothyroidism is relatively mild and lack non-specific and it might be overlooked due to other hormonal deficiencies. Replacement therapy for central hypothyroidism is titrated by arbitrary target free T4 levels of above 50th percentile of normal. The goal of our study is to compare the standard results from well known measure methods to a new method for measuring Ft4 using Liquid chromatography - tandem mass spectrometry.

Detailed Summary:
Sponsor: Sheba Medical Center

Current Primary Outcome: free T4 levels [ Time Frame: a year ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Symptoms of hypothyroidism [ Time Frame: a year ]

Original Secondary Outcome: Same as current

Information By: Sheba Medical Center

Dates:
Date Received: January 19, 2011
Date Started: February 2011
Date Completion: July 2013
Last Updated: February 2, 2011
Last Verified: February 2011