Clinical Trial: Postoperative Hyponatremia - Are There Gender Differences?

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Postoperative Hyponatremia - Are There Gender Differences?

Brief Summary: The proposed study will focus on anesthesia and anesthesia-induced hypotension as a possible cause for postoperative fluid retention and hyponatremia, and investigate gender differences in this response.

Detailed Summary: 30 healthy women and 30 healthy men, who are scheduled for surgery of the middle ear or parotic gland are included in the study. Within each gender group, the subjects are randomized to receive perioperative intravenous fluid regimes either based on body weight or lean body mass (LBM). The surgery lasts for at least 3 hours, the intervention period (fluid administration according to protocol) will last 10-12 hours, the study period will be 20-24 hours. Blood samples for analysis of plasma sodium, potassium, glucose and osmolality are collected preoperatively and the following morning together with analysis of urine produced during the study period.
Sponsor: Karolinska University Hospital

Current Primary Outcome: Change between preoperative and postoperative plasma sodium concentration [ Time Frame: 24 hrs ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Karolinska University Hospital

Dates:
Date Received: March 10, 2008
Date Started: March 2008
Date Completion: December 2013
Last Updated: June 11, 2013
Last Verified: June 2013