Clinical Trial: Treatment of Nasal Staphylococcus Aureus Colonization in Patients With HHT
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional
Official Title: Treatment of Nasal Staphylococcus Aureus Colonization in Patients With Hereditary Hemorrhagic Telangiectasia With Recurrent Epistaxis.
Brief Summary: Compare the frequency of epistaxis and quality of life related to nasal bleeding in patients with HHT colonized with sataphylococo before and after being treated with mupirocin ointment.
Detailed Summary:
Hereditary hemorrhagic telangiectasia is a vascular dysplasia characterized by the development of mucocutaneous telangiectasia and arteriovenous malformations in organs such as brain, lung, liver and tube digestivo. Is considered a rare disease, although It means that there is a substantial underdiagnosis. The overall prevalence is 1/5000.
Approximately 60% of the general population hosts strains of Staphylococcus aureus (S. aureus) intermittently and are called intermittent carriers, 20% represent persistent carriers harboring the same strain of S. aureus and 20% of the population are never carriers.
On this concept, one might think that HHT patients in whom there is an active and pathological vascular remodeling that causes bleeding, and inflammation is a known activator of abnormal angiogenesis; reducing an inflammatory factor as microbial through the eradication of nasal S. aureus could be useful to reduce bleeding in this population, directly impacting on quality of life.
Sponsor: Hospital Italiano de Buenos Aires
Current Primary Outcome: Nosebleed by sadick scale [ Time Frame: 60 days ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Prevalence of nasal colonization with Staphylococcus in patients with HHT by nasal cultive [ Time Frame: 60 days ]
Original Secondary Outcome: Same as current
Information By: Hospital Italiano de Buenos Aires
Dates:
Date Received: August 9, 2016
Date Started: June 2017
Date Completion: December 2017
Last Updated: November 9, 2016
Last Verified: November 2016
