Clinical Trial: Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)

Brief Summary: MDMA (3,4-Methylenedioxymethamphetamine, "Ecstasy") produces tachycardia, hypertension, hyperthermia, and other acute adverse effects. Ecstasy use has also been associated with rare cardio- and cerebrovascular complications. The role of beta-blockers in the treatment of cardiovascular and adverse effects of MDMA is unknown.

Detailed Summary: We investigated the interactive effects of the beta-blocker pindolol (20 mg) with MDMA (1.6 mg/kg) on heart rate, blood pressure, body temperature, and adverse effects in a double-blind placebo-controlled study in 16 healthy subjects.
Sponsor: University Hospital, Basel, Switzerland

Current Primary Outcome: Effect of pindolol on subjective response to MDMA [ Time Frame: 24h ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Effect of pindolol on physiological response to MDMA [ Time Frame: 24h ]

Original Secondary Outcome: Same as current

Information By: University Hospital, Basel, Switzerland

Dates:
Date Received: May 7, 2009
Date Started: June 2001
Date Completion:
Last Updated: June 12, 2009
Last Verified: June 2009