Clinical Trial: Probiotics for Birch Pollen Allergy
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Probiotic Intervention for Children With Birch Pollen Allergy
Brief Summary:
Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed to modulate the immune system. Since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy.
Earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. It was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.
Detailed Summary:
Sponsor: Danisco
Current Primary Outcome:
- Birch pollen allergy symptoms [ Time Frame: March/April and June ]
- Nasal Eosinophilia [ Time Frame: April/May and June ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Change in microbiota composition [ Time Frame: April/May and June ]
- Cytokine profile from serum [ Time Frame: April/May and June ]
- Faecal recovery of administered probiotics [ Time Frame: April/May and June ]
Original Secondary Outcome: Same as current
Information By: Danisco
Dates:
Date Received: September 2, 2008
Date Started: March 2006
Date Completion:
Last Updated: September 2, 2008
Last Verified: September 2008
