Clinical Trial: Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Exertional Rhabdomyolysis- Characterization of Prediction Tests for Return to Duty

Brief Summary: In order to determine norm values for skeleton muscle disassembly due to physical exertion in healthy and trained population, and developing a prediction test for approval for rhabdomyolysis injuries to return to duty, 50 healthy subjects will undergo a series of different physical tests.

Detailed Summary: 50 healthy civilians volunteers will be recruited for this study. Each subject will undergo the physical tests: anthropometric measurements, wingate test, VO2max test, step test and running on the anaerobic threshold, on separate days. Blood sample, lactic acid level (measured in blood drop - finger sting) and urine sample will be taken before and after every test.
Sponsor: Sheba Medical Center

Current Primary Outcome:

  • creatine phosphokinase (CPK) [ Time Frame: 5 experiment days for each subject ]
    CPK is a marker for muscle damage assessed in blood test. blood sample will be taken before and after step test and running on the anaerobic threshold test.
  • oxygen consumption (VO2) [ Time Frame: 5 experiment days for each subject ]
    VO2 will be monitored continuously using a metabolic system (ERGOTEST 680, ZAN, GERMANY ) during VO2max test, step test and running on the anaerobic threshold test.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • lactic acid [ Time Frame: 5 experiment days for each subject ]
    lactic acid level is assessed from blood drop (finger sting), will be taken before and after every test. lactic acid is a marker for anaerobic effort evaluating.
  • Myoglobin [ Time Frame: 5 experiment days for each subject ]
    marker from urine sample, taken before and after step test and running on the anaerobic threshold test.
  • Heart rate [ Time Frame: 5 experiment days for each subject ]
    The heart rate will be monitored using a wearable heart rate monitor (Polar® sensor and heart rate monitor watch).


Original Secondary Outcome: Same as current

Information By: Sheba Medical Center

Dates:
Date Received: July 13, 2015
Date Started: October 2015
Date Completion: December 2016
Last Updated: July 14, 2015
Last Verified: July 2015