Clinical Trial: Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Endogenous DNA Transposition in Rhabdoid Tumors

Brief Summary:

RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.

PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.

Detailed Summary:

OBJECTIVES:

• To investigate the expression and function of transposons in 50 primary rhabdoid tumors.

OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.

Sponsor: Children's Oncology Group

Current Primary Outcome: Expression and function of transposons in rhabdoid tumors

Original Primary Outcome: Expression and function of PGBD5 in rhabdoid tumors

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Children's Oncology Group

Dates:
Date Received: February 29, 2012
Date Started: March 2012
Date Completion:
Last Updated: May 17, 2016
Last Verified: May 2016