Clinical Trial: A Population-based Study of Macular Choroidal Neovascularization in a Chinese Population

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: A Population-based Study of Macular Choroidal Neovascularization Using Optical Coherence Tomography in a Chinese Population

Brief Summary: To investigate pathomorphological and functional variations of choroidal neovascularization (CNV) in age-related macular degeneration (AMD) in a Chinese population using optical coherence tomography (OCT) to find which kinds of Fundus characteristics indicated exudative AMD.

Detailed Summary: This population-based study enrolled 59 patients (>45 years old; 70 eyes) with early and intermediate-stage AMD from Youyi Street, Baoshan District, Shanghai, China. Comprehensive standardized ophthalmic examinations included visual acuity, anterior segment analysis by slit lamp, dilated fundus evaluation by direct ophthalmoscopy, 90D handheld lens, fundus photography, fluorescein angiography (FFA), and fast optic disk scans using OCT. The macular CNV characteristic profiles in early and intermediate-stage AMD were determined by OCT. Data were obtained at first visit and 6 to 24 months follow-up, and FFA and OCT outcomes of early and intermediate-stage AMD patients were analyzed.
Sponsor: Shanghai University of Traditional Chinese Medicine

Current Primary Outcome: change of the early and intermediate-stage AMD [ Time Frame: May 2004-September 2008 ]

Drusen with unclear boundaries and obvious pigment proliferation, with hypofluorescence around drusens seen on FFA and a slight small arch field located in the retinal pigment epithelium (RPE)/choriocapillary layer (CCL) on OCT indicated exudative AMD.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Shanghai University of Traditional Chinese Medicine

Dates:
Date Received: August 14, 2012
Date Started: May 2004
Date Completion:
Last Updated: August 14, 2012
Last Verified: August 2012