Clinical Trial: Comparison of Effects of PEEP Levels on Respiratory Mechanics in Patients Undergoing Laparoscopic Cholecystectomy

Study Status: Completed
Recruit Status: Completed
Study Type: Observational [Patient Registry]

Official Title: Comparison of Effects of 3 Different PEEP Levels on Hemodynamic, Respiratory Mechanics and Elimination of Volatile Anesthetic Agent in Patients Undergoing Laparoscopic Cholecystectomy

Brief Summary: Laparoscopic cholecystectomy is accepted as gold standard in the management of cholelithiasis. Although laparoscopic procedures have many advantages,intra-abdominal CO2 insufflation can cause decreased lung volumes and compliance, increased airway resistance and impaired ventilation-perfusion ratio. In this study, investigators aim to investigate effects of intra-operative PEEP treatment at 3 distinct levels on respiratory dynamics and elimination time of volatile anesthetic agent.

Detailed Summary: In the study, 75 ASA I-II patients aged 30-65 years will be randomized into 3 groups to receive 0 cmH2O PEEP (Group-1), 5 cmH2O PEEP (Group-2) and 8 cmH2O PEEP (Group-3) in PVC mode. In all patients underwent general anesthesia; hemodynamic parameters, Ppeak, Pplateau, compliance values as well as Fisevo/Fexpsevo ratio at 1 MAC and times from 1 MAC to 0.3 and 0.1 MAC will be recorded. In addition, preoperative and postoperative pulmonary function tests will be compared in all patients.
Sponsor: Umraniye Education and Research Hospital

Current Primary Outcome: levels of static-dynamic compliance with intra-operative PEEP treatment at 3 distinct levels [ Time Frame: 1 month ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • elimination time of volatile anesthetic agent with intra-operative PEEP treatment at 3 distinct levels [ Time Frame: 1 month ]
  • levels of p peak and p plateau pressures with intra-operative PEEP treatment at 3 distinct levels [ Time Frame: 1 month ]


Original Secondary Outcome: Same as current

Information By: Umraniye Education and Research Hospital

Dates:
Date Received: May 3, 2015
Date Started: March 2015
Date Completion:
Last Updated: May 6, 2015
Last Verified: May 2015