Clinical Trial: Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction

Study Status: Enrolling by invitation
Recruit Status: Enrolling by invitation
Study Type: Observational

Official Title: Construction of a Database to Identify Early Indicators of Respiratory Muscle Dysfunction in Neuromuscular Patients From the Optoelectronic Plethysmography Assessment of the Thoracoabdominal Motion

Brief Summary: The aim of this study is to better discriminate respiratory muscle dysfunction by comparing the measurements of thoracoabdominal motion obtained by an optoelectronic recording and the conventional tests of respiratory muscle strength. The final objective is to better select in the future the patients who need more specific assessment of diaphragmatic function like "maximal transdiaphragmatic pressure" measurement and "phrenic nerve stimulation".

Detailed Summary:

All patients which had suspected respiratory muscle dysfunction will have usual exploration of the respiratory muscles according to the clinician prescription. These explorations can include :

  • Lung volumes in seating and supine position
  • Maximal inspiratory and expiratory pressures
  • Maximal sniff pressures

And when diaphragmatic dysfunction is suspected :

  • Maximal transdiaphragmatic pressure
  • Phrenic nerve conduction

These patients will also beneficiate to the determination of volume variations of the upper rib cage, the lower rib cage and the abdominal compartments by using Opto-electronic plethysmography.


Sponsor: Centre d'Investigation Clinique et Technologique 805

Current Primary Outcome: compartmental distribution of the inspired/expired volumes [ Time Frame: 1 hour ]

Measurements of the thoraco-abdominal motion and of the global lung volume changes.

Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and for each compartiment (upper thorax, lower thorax, abdomen) contribution of these volumes will be expressed in percentage.



Original Primary Outcome:

  • compartmental distribution of the inspired/expired volumes [ Time Frame: 1 hour ]

    Measurements of the thoraco-abdominal motion and of the global lung volume changes.

    Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and for each compartiment (upper thorax, lower thorax, abdomen) contribution of these volumes will be expressed in percentage.

  • Abdominal contribution to the inspired volume [ Time Frame: 1 hour ]
    Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and abdominal contribution of these volumes will be expressed in percentage.


Current Secondary Outcome: left side and right side contribution to the inspired/expired volumes [ Time Frame: 1 hour ]

Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and each side contribution of these volumes will be expressed in percentage.


Original Secondary Outcome: Same as current

Information By: Centre d'Investigation Clinique et Technologique 805

Dates:
Date Received: March 27, 2012
Date Started: June 2011
Date Completion: July 2018
Last Updated: April 28, 2017
Last Verified: April 2017