Clinical Trial: Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Influence of Positive End-expiratory Pressure on the Cerebrovascular Autoregulation in Patients With Respiratory Failure
Brief Summary: The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
Detailed Summary: Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.
Sponsor: Johannes Gutenberg University Mainz
Current Primary Outcome: Change from Baseline cerebrovascular autoregulation due to elevated positive end-expiratory pressure [ Time Frame: 1 Year ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Johannes Gutenberg University Mainz
Dates:
Date Received: June 14, 2011
Date Started: January 2011
Date Completion:
Last Updated: June 17, 2011
Last Verified: August 2010