Clinical Trial: Immune Responses After a Four-site Intradermal Rabies Booster Vaccination in HIV-infected Adults

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Humoral and Cell-mediated Immune Responses After a Four-site Intradermal Rabies Booster Vaccination in Previously Rabies Immunized HIV-infecte

Brief Summary: A four-site intradermal rabies booster vaccination in HIV - infected patients who have ever received primary rabies vaccination could improve their immune response to this kind of vaccine.

Detailed Summary: A four-site intradermal rabies booster vaccination has shown higher immune response than conventional intramuscular rabies booster vaccination in healthy persons. So, the investigators hypothesized the same outcome in HIV - infected patients.
Sponsor: Queen Saovabha Memorial Institute

Current Primary Outcome: Rabies neutralizing antibody titers [ Time Frame: Change from baseline of geometric mean titres of rabies neutralizing antibody titres at 2 weeks ]

Rabies neutralizing antibody titers would be represented and compared by geometric mean titers (GMTs)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Specific T cell response [ Time Frame: Change from baseline of percentages of rabies-antigen specific CD4+ T cells at 2 weeks ]
    Specific T cell response is measured by OX-40 assay
  • Cytokines assessment [ Time Frame: Change from baseline of cytokines levels at 1 week ]
    A few cytokines levels are measured by multiplex bead array assay


Original Secondary Outcome: Same as current

Information By: Queen Saovabha Memorial Institute

Dates:
Date Received: September 9, 2015
Date Started: February 2016
Date Completion: December 2018
Last Updated: November 23, 2016
Last Verified: November 2016