Clinical Trial: Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional
Official Title: Intravenous Saline on Exercise Tolerance in Orthostatic Intolerance
Brief Summary: The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
Detailed Summary:
Sponsor: Vanderbilt University
Current Primary Outcome: Difference in VO2max between saline day and placebo day [ Time Frame: Within 2 week ]
Original Primary Outcome: Difference in VO2max between saline day and placebo day [ Time Frame: 2-10 Days between exercise tests ]
Current Secondary Outcome:
- Exercise capacity/Maximal Load (Watts) during peak VO2 [ Time Frame: Less than 2 weeks ]Maximal exercise load will be measured hours after saline and after placebo. The 2 interventions will be less than 2 weeks apart.
- Cardiac output between exercise tests (inert gas rebreathing technique) [ Time Frame: 2-10 Days between exercise tests ]
Original Secondary Outcome:
- Exercise capacity/Maximal Load (Watts) during peak VO2 [ Time Frame: 2-10 Days between exercise tests ]
- Cardiac output between exercise tests (inert gas rebreathing technique) [ Time Frame: 2-10 Days between exercise tests ]
Information By: Vanderbilt University
Dates:
Date Received: October 21, 2009
Date Started: October 2009
Date Completion: June 2017
Last Updated: August 15, 2016
Last Verified: August 2016