Clinical Trial: Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Intravenous Saline on Exercise Tolerance in Orthostatic Intolerance

Brief Summary: The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).

Detailed Summary:
Sponsor: Vanderbilt University

Current Primary Outcome: Difference in VO2max between saline day and placebo day [ Time Frame: Within 2 week ]

VO2max will be measured hours after saline and after placebo. The 2 interventions will be less than 2 weeks apart.


Original Primary Outcome: Difference in VO2max between saline day and placebo day [ Time Frame: 2-10 Days between exercise tests ]

Current Secondary Outcome:

  • Exercise capacity/Maximal Load (Watts) during peak VO2 [ Time Frame: Less than 2 weeks ]
    Maximal exercise load will be measured hours after saline and after placebo. The 2 interventions will be less than 2 weeks apart.
  • Cardiac output between exercise tests (inert gas rebreathing technique) [ Time Frame: 2-10 Days between exercise tests ]


Original Secondary Outcome:

  • Exercise capacity/Maximal Load (Watts) during peak VO2 [ Time Frame: 2-10 Days between exercise tests ]
  • Cardiac output between exercise tests (inert gas rebreathing technique) [ Time Frame: 2-10 Days between exercise tests ]


Information By: Vanderbilt University

Dates:
Date Received: October 21, 2009
Date Started: October 2009
Date Completion: June 2017
Last Updated: August 15, 2016
Last Verified: August 2016