Clinical Trial: Analysis of CMV Infections in Patients With Brain Tumors or Brain Metastases During and After Radio(Chemo)Therapy
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Analysis of CMV Infections in Patients Suffering From Brain Tumors and Brain Metastases During and After Radio(Chemo)Therapy
Brief Summary: Radio(chemo)therapy is the standard therapy for both, brain tumors and brain metastases. Neurological decline is observed in these patients and tumor progression or radiotherapy side effects have been made responsible for this. However CMV encephalitis may also be a reason. Therefore the investigators aim to analyze the CMV status in patients during and after radio(chemo)therapy. It will be checked by CMV-DNA (PCR analysis) and CMV antibodies (IgG and IgM ELISA) in the blood of the patients. These findings will be correlated with changes in the brain, visualized by MRI. In addition a detailed immunophenotyping in the peripheral blood will be performed.
Detailed Summary:
Sponsor: University of Erlangen-Nürnberg Medical School
Current Primary Outcome: Change of CMV status during radio(chemo)therapy (RCT) [ Time Frame: up to day 45 after start of Radiotherapy ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Change of circulating immune cells of treated patients by deep immunophenotyping. [ Time Frame: up to month 6 after the start of Radiotherapy ]
Original Secondary Outcome: Same as current
Information By: University of Erlangen-Nürnberg Medical School
Dates:
Date Received: October 23, 2015
Date Started: November 2014
Date Completion: November 2019
Last Updated: November 24, 2016
Last Verified: November 2016