Clinical Trial: The Effect and Safety of Low Dose Nebulized Epinephrine in Croup

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: The Effect and Safety of Low Dose Nebulized Epinephrine in the Treatment of Croup

Brief Summary:

Croup is common illness presenting emergency department with dyspnea. The main treatment for croup is nebulized L-epinephrine and steroid. The study for the dose of nebulized L-epinephrine is restricted that the study of comparision between racemic epinephrine and L-epinephrine.

The investigators conducted this study to compare the effectiveness of low dose L-epinephrine with conventional dose L-epinephrine.


Detailed Summary:
Sponsor: Seoul National University Hospital

Current Primary Outcome: the difference of Westley croup score between baseline and 30 minutes after neublized treatment [ Time Frame: 30 minutes ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • the incidence of use of additional neublized treatment [ Time Frame: 30 minutes ]
  • Westley croup score [ Time Frame: 30, 60, 90, 120, 180, 240 minutes ]
  • the side effect of epinephrine [ Time Frame: participants will be followed for the duration of ED stay ]
    Hypertension, tachycardia : more than 95th percentile for age Arrythmia Pallor Tremor
  • respiratory rate, oxygen saturation [ Time Frame: 30, 60, 90, 120, 180, 240 minutes ]
  • health care utilization- length of stay in emergency department, admission rate, revisit dut to croup symptom [ Time Frame: within 7 days ]
  • treatment failure [ Time Frame: 30min after 2nd epinephrine nebulizer ]
    after additional nebulized epineprhine at 30 minutes, as the croup scrore is higher than baselin, the blinding is cleared.
  • rebound effect [ Time Frame: 180 minutes ]
    the croup score is the same or over than the base line


Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: August 3, 2012
Date Started: September 2012
Date Completion: August 2013
Last Updated: August 9, 2012
Last Verified: August 2012