Clinical Trial: Active Bathing to Eliminate Infection (ABATE Infection) Trial

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Cluster-Randomized Controlled Trial of Hospitals to Reduce Healthcare-Associated Infections and Readmissions Through Routine Bathing With Antiseptic Soap and Targeted Use

Brief Summary:

The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are:

  • Arm 1: Routine Care Routine policy for showering/bathing
  • Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen

Note that enrolled "subjects" represents 53 individual HCA Hospitals (representing ~190 non-critical care units) that have been randomized.


Detailed Summary:
Sponsor: University of California, Irvine

Current Primary Outcome: MRSA and VRE clinical cultures [ Time Frame: 18 months ]

Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) clinical cultures attributable to participating units. Defined as occurring >2 days into a participating unit stay through 2 days following unit discharge


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Gram-negative multi-drug resistant organism clinical cultures [ Time Frame: 18 months ]
    Gram-negative (GN) multi-drug resistant organism clinical cultures attributable to participating units. Defined as occurring >2 days into a participating unit stay through 2 days following unit discharge
  • All-cause bloodstream infections [ Time Frame: 18 months ]
    All-cause bloodstream infections attributable to participating units. Defined as occurring >2 days into a participating unit stay through 2 days following unit discharge. Includes subsets of gram positive (GP) and gram negative (GN) MDROs as well as key pathogens such as S. aureus.


Original Secondary Outcome: Same as current

Information By: University of California, Irvine

Dates:
Date Received: February 12, 2014
Date Started: April 2014
Date Completion: December 2018
Last Updated: October 25, 2016
Last Verified: October 2016