Clinical Trial: Monitoring Response to Antiplatelet Therapy

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Pilot Study Investigating the Use of a Variety of Assays to Detect Individual Response to Antiplatelet Therapy

Brief Summary: Antiplatelet therapy plays a key role in the prevention of complications related to coronary angioplasty and stenting (PCI) including procedure related myocardial damage. Aspirin and clopidogrel are now universally prescribed in patients undergoing these procedures. However, loading and maintenance doses have not been established and variation in individual response is emerging. New tests to assess the effects of these drugs are being developed but have yet to be incorporated into routine clinical practice. We will assess the effects of aspirin and clopidogrel in a consecutive series of patients undergoing angioplasty using new assays which can be carried out at the bedside. We will compare the results with alternative laboratory based tests and look for an association between the results, peri-procedural myocardial necrosis and subsequent cardiovascular events.

Detailed Summary:
Sponsor: NHS Greater Glasgow and Clyde

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: NHS Greater Glasgow and Clyde

Dates:
Date Received: May 15, 2006
Date Started: January 2006
Date Completion: September 2006
Last Updated: May 15, 2006
Last Verified: May 2006