Clinical Trial: Comparison of Two Method Antimetabolites Application on Corneal Function in Trabeculectomy Surgery

Study Status: Suspended
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Corneal Endothelial Cell Loss Following Trabeculectomy With mitomycin_c Application Before Versus After Sclera Flap Dissection

Brief Summary: Application of antimetabolite agents such as mitomycin_c has improved trabeculectomy results and better control of intraocular pressure complications such as corneal endothelial cell loss. However, Mitomycin_c can be applied remain a concern before or after sclera flap dissection. Mitomycin_c application after sclera flap dissection probably increases corneal endothelial cell loss. This study compares Mitomycin_c application two methods: before and after sclera flap dissection with regard to success rate and complication. patients on base of Mitomycin_c application time (1-2-3) minutes will be match randomise in to two groups( before and after sclera flap dissection) corneal. Endothelial cell density, polymorphism, polymegathism and intraocular pressure before and one month, three months, six months after surgery will measured.

Detailed Summary:
Sponsor: Shahid Beheshti University of Medical Sciences

Current Primary Outcome:

  • corneal endothelial cell density [ Time Frame: six month ]
    specular microscopy
  • corneal endothelial cell polymorphism [ Time Frame: 6 months ]
    specular microscopy
  • corneal endothelial cell polymegathism [ Time Frame: 6 months ]
    specular microscopy


Original Primary Outcome: Same as current

Current Secondary Outcome: IOP (intra ocular pressure) [ Time Frame: six months ]

applanation tonometry


Original Secondary Outcome: Same as current

Information By: Shahid Beheshti University of Medical Sciences

Dates:
Date Received: January 19, 2011
Date Started: November 2010
Date Completion: December 2011
Last Updated: February 16, 2011
Last Verified: November 2010