Clinical Trial: Functional Antigen Matching in Corneal Transplantation

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Clinical Trial to Investigate Superiority of HLA Matching in Comparison to Random Graft Assignment With Respect to the Endpoint 'Time to First Endothelial Graft Rejection' in Penetrating Keratoplasty.

Brief Summary: Penetrating keratoplasty is one of the most commonly performed transplantation surgeries. Graft rejection is a major complication. HLA compatibility has already been demonstrated an effective prophylaxis in several retrospective investigations. The purpose of the investigators randomized clinical trial is to demonstrate superiority of HLA matching in comparison to random graft assignment with respect to the endpoint 'time to first endothelial graft rejection' in penetrating keratoplasty. The investigators will perform DNA-based allele resolution typing.

Detailed Summary:
Sponsor: University Hospital Freiburg

Current Primary Outcome: Time to first endothelial graft rejection. [ Time Frame: Mostly within the first six months. ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital Freiburg

Dates:
Date Received: December 17, 2008
Date Started: September 2009
Date Completion:
Last Updated: October 24, 2016
Last Verified: October 2016