Clinical Trial: Botulinum Toxin A to Treat Flexion Contracture After Total Knee Arthroplasty

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Botulinum Toxin A to Treat Flexion Contracture After Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Study

Brief Summary: The goal of this research project is to evaluate injections of botulinum toxin A (Botox) as the treatment for knee flexion contracture after total knee arthroplasty (TKA). The current treatment for patients who do not achieve full extension of the knee (flexion contracture) after TKA consists of an aggressive physical therapy program, home stretching program, and the use of an extension orthosis (brace). Many patients do not tolerate wearing these braces. This initial project is designed to use injections of Botox as an adjunct to the standard current treatment and evaluate its efficacy. It is our hypothesis that a single injection into the hamstrings in addition to routine postoperative rehabilitation will result in improved knee extension and this improvement in function should endure without further treatment.

Detailed Summary:
Sponsor: Rothman Institute Orthopaedics

Current Primary Outcome: Range of Motion: knee [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Rothman Institute Orthopaedics

Dates:
Date Received: April 8, 2013
Date Started: August 2012
Date Completion:
Last Updated: December 12, 2013
Last Verified: December 2013