Clinical Trial: Studying Biomarkers in Samples From Younger Patients With Kidney Cancer

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Observational

Official Title: Focal Adhesion Kinase Expression in Pediatric Renal Tumors

Brief Summary: This laboratory study is looking into biomarkers in samples from younger patients with kidney cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

Detailed Summary:

PRIMARY OBJECTIVES:

I. To determine whether focal adhesion kinase (FAK) is expressed and if FAK is phosphorylated in pediatric renal tumors.

OUTLINE:

Archived tumor tissue samples are analyzed for FAK expression by immunohistochemistry (IHC). IHC staining is compared in normal renal tissue, Wilms tumor (routine and anaplastic), malignant rhabdoid tumor of the kidney, clear cell sarcoma of the kidney, and mesoblastic nephroma.

Sponsor: Children's Oncology Group

Current Primary Outcome: FAK expression in pediatric renal tumors [ Time Frame: Baseline ]

Original Primary Outcome: FAK expression in pediatric renal tumors

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Children's Oncology Group

Dates:
Date Received: July 15, 2012
Date Started: August 2012
Date Completion:
Last Updated: February 14, 2014
Last Verified: February 2014