Clinical Trial: Gene Function in Bone Marrow Cells From Patients With Fanconi Anemia and From Healthy Participants
Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational
Official Title: Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells
Brief Summary:
RATIONALE: Studying samples of bone marrow from patients with Fanconi anemia and from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to Fanconi anemia.
PURPOSE: This laboratory study is evaluating gene function in bone marrow cells from patients with Fanconi anemia and from healthy participants.
Detailed Summary:
OBJECTIVES:
- Describe the complete hematopoietic transcriptomes of Fanconi cells of every common complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic cells derived from bone marrow of patients with Fanconi anemia.
- Define large-scale dynamic gene expression data in these patients.
OUTLINE: This is a multicenter study.
Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological studies. Samples are analyzed for gene expression profiles using microarray assays.
PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this study.
Sponsor: OHSU Knight Cancer Institute
Current Primary Outcome:
- Comparison of Fanconi anemia (FA) hematopoietic cells vs normal hematopoietic cells
- Comparison of FA hematopoietic cells from children with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) vs children (siblings) with FA but without MDS/AML
- Comparison of FA cells from different complementation groups
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: OHSU Knight Cancer Institute
Dates:
Date Received: May 9, 2009
Date Started: March 2002
Date Completion:
Last Updated: November 20, 2012
Last Verified: October 2007
