Clinical Trial: Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: The Effect of L-Dopa on the Progression of Retinitis Pigmentosa

Brief Summary: The purpose of this study is to evaluate the effect of L-Dopa on the progression of retinitis pigmentosa.

Detailed Summary: Retinitis pigmentosa is a group of progressive hereditary diseases that diffusely affects the functioning of photoreceptors and the pigment epithelium. It may be speculated that a protective effect on the pigment epithelium, as it is supposed for L-Dopa, can slow the progression of the disease or even lead to an, at least transient, improvement of visual functions. To evaluate the effect of L-Dopa on retinitis pigmentosa progression, visual acuity, electroretinogram and visual field will be preformed regularly.
Sponsor: Beirut Eye Specialist Hospital

Current Primary Outcome: Change in Electroretinogram [ Time Frame: Baseline, 1 year, 2 years, 5 years ]

the electric response to light stimuli of the retina, in millivolt, will be measured. The electroretinogram shows a-waves (elicit information about the function of the photoreceptors) and b-waves (elicit information about other neurosensory structure of the retina)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change in Visual Acuity [ Time Frame: Baseline, 6 months, 1 year, 2 years, 5 years ]
    Visual acuity will be measured using Snellen chart
  • Change in Visual Field [ Time Frame: Baseline, 1 year, 2 years, 5 years ]
    Using 24-2 Humphrey Visual Field Analyzer, the progress in visual field defect will be measured, comparing mean deviation (dB) and pattern standard deviation (dB)


Original Secondary Outcome: Same as current

Information By: Beirut Eye Specialist Hospital

Dates:
Date Received: June 22, 2016
Date Started: June 2016
Date Completion: June 2021
Last Updated: July 15, 2016
Last Verified: July 2016