Clinical Trial: Attention Training for Childhood Obsessive Compulsive Disorder: An Open Case Series
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Attention Training for Childhood Obsessive Compulsive Disorder: An Open Case Series
Brief Summary:
Pediatric Obsessive Compulsive Disorder (OCD) is a chronic, impairing condition that accrues significant concurrent and long-term risk to affected youth. Although empirically supported psychosocial and pharmacological treatments for OCD exist, many children and their families are not able to adequately access these treatments or derive only partial benefit from them. Such findings highlight the importance of developing more effective treatment options which have the potential to be widely accessible to OCD youth.
The investigators are proposing to test a computerized attention modification program, AMP, in six youth with OCD in an open case series to gather information regarding protocol acceptability, feasibility and preliminary efficacy. This phase includes the development and refinement of stimuli selection procedures, behavior avoidance task, EEG protocol, and AMP parameters for use with children.
Following ascertainment of study eligibility, participants will undergo a baseline assessment consisting of a clinical interview, neurocognitive assessments, EEG, attention bias assessment, and self report questionnaires. Study participants will then receive 12 sessions of AMP treatment over the course of three weeks. All youngsters and their families will be reassessed at treatment endpoint (week 4). Participation will take a total of about 24 hours over the course of six weeks. Participants who are treatment responders may be asked to return approximately 3 months after completing treatment for a follow-up assessment.
Preliminary hypotheses: 1) AMP will be acceptable to youth and families and feasible to administer; 2) Youth receiving AMP will demonstrate decreases in threat bias and OCD symptom severity.
Detailed Summary:
Sponsor: University of California, Los Angeles
Current Primary Outcome: Children's Yale-Brown Obsessive Compulsive Scale Change From Pre-Treatment to Post-Treatment [ Time Frame: pre-treatment (week 0) and post-treatment (week 5) ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Clinical Global Impression-Severity (CGI-S) and Improvement (CGI-I) Scales Change From Pre-Treatment to Post-Treatment [ Time Frame: pre-treatment (week 0) and post-treatment (week 5) ]
- Attention Bias Assessment Change from Pre-Treatment to Post-Treatment [ Time Frame: pre-treatment (week 0) and post-treatment (week 5) ]Computerized assessment of attention bias
Original Secondary Outcome: Same as current
Information By: University of California, Los Angeles
Dates:
Date Received: October 11, 2012
Date Started: November 2012
Date Completion:
Last Updated: January 13, 2017
Last Verified: January 2017
