Clinical Trial: Clinical Evaluation of Narrow Band Imaging Colonoscope

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Tandem Colonoscopy Study of Narrow Band Imaging Versus White Light Examination to Compare Neoplasia Miss Rates

Brief Summary: The purpose of the study is to determine if colonoscopic examination using a colonoscope with a narrow band imaging light is more effective at detecting polyps compared to a colonoscope with standard full spectrum white light.

Detailed Summary: This is a clinical study to evaluate whether the use of a new type of colonoscope may improve the detection of colon polyps. Though colonoscopy is currently the best test for colon cancer screening, it remains imperfect. Research has found that about 25% of polyps may actually be missed during colonoscopy using standard full spectrum white light imaging. Advances in colonoscopic technology hold the potential to decrease the miss rate of colorectal neoplasms. A new colonoscope uses narrow band imaging, whereby the colon is illuminated using only a subset of the white light spectrum, 415nanometers (blue) and 540 nanometers (green) rather than the standard full spectrum white light (red, green and blue). Initial studies by other groups suggest that these narrow band images highlight small blood vessels of colon polyps. As such, we hypothesized that the use of NBI would improve the identification of neoplasms through the color differentiation of precancerous or cancerous polyp (appearing brown) from normal colon mucosal lining (appearing green), and potentially lead to a reduction in polyp miss rate. We aimed to study the polyp miss rate, and compare narrow band imaging to white light examination.
Sponsor: VA Palo Alto Health Care System

Current Primary Outcome: Neoplasm Miss Rate [ Time Frame: same day ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Neoplasm Detection Rates [ Time Frame: same day ]
  • Completion of Examinations [ Time Frame: same day ]
  • Procedure Complications [ Time Frame: procedure and post-procedure complications within 30 days after colonoscopy ]


Original Secondary Outcome: Same as current

Information By: VA Palo Alto Health Care System

Dates:
Date Received: February 25, 2008
Date Started: January 2006
Date Completion:
Last Updated: January 17, 2017
Last Verified: January 2017