Clinical Trial: Recovery Improved in Covert Stroke With Exercise

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Achieving Brain Benefits in Covert Stroke Through Aerobic Exercise

Brief Summary: Silent ischemic, also known as "covert stroke vascular disease" (CSVD), contributes to neurological deficits that are caused by damage to small blood vessels in the brain. CSVD occurs six to ten times more often that an acute stroke. It is misleading to think, however, that CSVD is an inevitable part of "getting old" because people with CSVD are at high risk of developing an acute stroke or dementia. In fact, people with more CSVD lesion volume are more likely to develop day to day problems in planning, decision-making and speed of thinking. Unfortunately, there are no proven therapies designed to address CSVD. We propose to test whether aerobic exercise is an intervention that can combat CSVD because the disease is fundamentally a blood flow problem that may be improved by aerobic exercise. We will recruit CSVD adults with moderate to severe lesion burden and use magnetic resonance imaging (MRI) to study the brain in terms of structure, perfusion and function. Participants will be randomly assigned to either our established aerobic exercise program or a control stretching program. Both groups will take part in lab exercise sessions, which are designed to monitor progress and assess adherence to the program. The duration and intensity of their exercise will increase as participants progress. We will use activity log books, phone calls and extra "booster" exercise sessions, as needed, to maximize retention and adherence. We aim to show that aerobic exercise increases cerebral blood flow (CBF) in frontal-subcortical grey matter, supports regional tissue growth, and improves cognitive function in CSVD adults with substantial risk of acute stroke and dementia. A positive outcome of this research will provide strong support for additional clinical trials aimed at sustaining cognition and maintaining independent living.

Detailed Summary:
Sponsor: Sunnybrook Health Sciences Centre

Current Primary Outcome:

  • Cerebral blood flow [ Time Frame: up to 12 months ]
    Pseudo-continuous arterial spin labeling MRI (pcASL) to quantify cerebral blood flow
  • Brain structure [ Time Frame: up to 12 months ]
    Cortical and subcortical grey matter density using MRI


Original Primary Outcome: Same as current

Current Secondary Outcome: Brain activity related to attention and executive control [ Time Frame: 0, 6, and 12 months ]

Functional MRI


Original Secondary Outcome: Same as current

Information By: Sunnybrook Health Sciences Centre

Dates:
Date Received: February 19, 2014
Date Started: May 2014
Date Completion: May 2019
Last Updated: November 16, 2015
Last Verified: November 2015