Clinical Trial: Esmolol Infusion in Patients Undergoing Craniotomy
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Esmolol Reduces Anesthetic Requirements Thereby Facilitating Early Extubation; a Prospective Controlled Study in Patients Undergoing Intracranial Surgery
Brief Summary: Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative stimuli and so it might interfere in the effect of the anesthetic drugs on the brain. This study was designed to investigate the effect of esmolol on the consumption of propofol and sevoflurane in patients undergoing craniotomy.
Detailed Summary:
Patients undergoing elective craniotomy for aneurysm clipping or tumor dissection were randomly divided in two groups (four subgroups). Anesthesia was induced with propofol, fentanyl and a single dose of cis-atracurium, followed by continuous infusion of remifentanil and either propofol or sevoflurane. Patients in the esmolol group received 500 mcg/kg of esmolol bolus 10 min before induction of anesthesia, followed by additional 200 mcg/kg/min of esmolol. Monitoring of the depth of anesthesia was also performed using the Bispectral Index-BIS. It was also performed monitoring of the cardiac output in order to evaluate the effect of esmolol on cardiac output.
The inspired concentration of sevoflurane and the infusion rate of propofol were adjusted in order to maintain a BIS value between 40-50.
Intraoperative emergence was detected by the elevation of BIS value, HR or MAP.
It was recorded intraoperative fluctuations of propofol and sevoflurane in both groups. Data were expressed as mean ± SD. Differences in categorical data were evaluated using the student t test.
Sponsor: George Papanicolaou Hospital
Current Primary Outcome: systolic arterial pressure fluctuation [ Time Frame: intraoperative ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- extubation time [ Time Frame: at time of surgery ]
- Heart rate [ Time Frame: intraoperative ]
- effect of esmolol on anesthetic's concentration [ Time Frame: intraoperative ]
Original Secondary Outcome: Same as current
Information By: George Papanicolaou Hospital
Dates:
Date Received: May 9, 2015
Date Started: March 2014
Date Completion:
Last Updated: July 7, 2015
Last Verified: July 2015
