Clinical Trial: Impact of Cerebellar Mass Resection on Pain Processing

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: The Impact of Cerebellar Mass Resection on Pain Processing

Brief Summary: The purpose of the study is to evaluate how cerebellar resection surgery may affect pain sensation and the way the brain "reads" pain signals. By measuring brain activity in children and adolescents following surgery, the investigators hope to gain valuable information about pain processing in the brain.

Detailed Summary: This study is designed to test whether cerebellar resection surgery affects pain pathways in the brain. To participate a participant must (A) have had a cerebellar mass surgically removed, or (B) are a healthy volunteer with no history of pain disorders or mental illness. The study will involve sensory testing and brain imaging using magnetic resonance imaging (MRI) Sensory testing will be performed using a tub of cold water, as well as a contact thermode capable of delivering hot and cold temperatures. MRI brain scanning uses magnetic fields and radio waves to give pictures of the brain without using radiation.
Sponsor: Dana-Farber Cancer Institute

Current Primary Outcome: Increase in blood oxygen level dependent signal response [ Time Frame: Baseline, Day 1 ]

Functional magnetic resonance imaging scans will be collected to measure blood oxygen level dependent (BOLD) responses, an indirect measure measure of neural activity. The Unit of Measure is % BOLD signal change across spatiotemporal domains within the brain.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Fear of Pain Questionnaire-Child scores [ Time Frame: Baseline, Day 1 ]
  • Multidimensional Anxiety Scale for Children scores [ Time Frame: Baseline, Day 1 ]
  • Behavior Rating Inventory of Executive Function scores [ Time Frame: Baseline, Day 1 ]
  • Fear of Pain Questionnaire III-Adult scores [ Time Frame: Baseline, Day 1 ]
  • Multidimensional Anxiety Questionnaire-Adult scores [ Time Frame: Baseline, Day 1 ]
  • Behavior Rating Inventory of Executive Function-Adult version scores [ Time Frame: Baseline, Day 1 ]


Original Secondary Outcome:

  • Fear of Pain Questionnaire-Child scores [ Time Frame: Baseline, Day 1 ]
  • Multidimensional Anxiety Scale for Children scores [ Time Frame: Baseline, Day 1 ]
  • Behavior Rating Inventory of Executive Function scores [ Time Frame: Baseline, Day 1 ]


Information By: Dana-Farber Cancer Institute

Dates:
Date Received: October 2, 2014
Date Started: October 2014
Date Completion: May 2017
Last Updated: February 6, 2017
Last Verified: February 2017