Clinical Trial: The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycin
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effects of Daptomycin in the Levels of IL-1, IL-6 and TNF in Patients With Complicated Cellulitis/Erisipela in Comparison With Vancomycin or Oxacillin
Brief Summary: Primary: To determine the influence of daptomycin on inflammatory cytokine (IL-1, TNF and IL-6) for the treatment of complicated cellulitis/erysipela compared with alternative treatment (vancomycin or oxacillin). Secondary: To evaluate the clinical outcome of both groups according to levels of the cytokines evaluated.
Detailed Summary:
Sponsor: Hospital Universitario Evangelico de Curitiba
Current Primary Outcome: Cytokine levels [ Time Frame: AUC will be calculated with multiple time points over a period of 14 days (0, 4, 8, 12 , 16, 24, 48, 72, 96, 120 and 168 hours post‐dose) ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Hospital Universitario Evangelico de Curitiba
Dates:
Date Received: March 23, 2012
Date Started: July 2012
Date Completion:
Last Updated: March 19, 2015
Last Verified: March 2015