Clinical Trial: Improving the Understanding of Catatonia in Autism

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Improving the Understanding of Catatonia in Autism

Brief Summary: Catatonia is a neuropsychiatric syndrome which is frequently missed or misdiagnosed among psychiatric patients. The current project is a systematic examination of catatonia which will characterize the phenotype and identify biological correlates that play a central role in the pathophysiology and effective pharmacological treatment of this condition.

Detailed Summary:

The specific aims of the study are to:

  1. Identify and phenotype participants ranging in age from 10-30 years old who are already diagnosed with catatonia.
  2. Review laboratory investigations already complete and further conduct any laboratory tests which were not previously completed, to exclude a general medical etiology of catatonia.
  3. Obtain skin biopsy for fibroblast from participant to reprogram somatic cells to iPSC (induced pluripotent cell lines) which will be differentiated to cortical neurons for in vitro pharmacological studies against the target tissue.

Up to 30 patients will be consented. Eligibility will be determined through UM medical record screening. When a potential participant is identified, the study team will reach out to the treating clinician to make contact with participant about research interest. Informed consent will be obtained prior to initiation of any study-related procedures. Consent may be emailed at request of potential participants or their representative in advance of a scheduled research appointment for their review. Additionally, informed consent will take place in person both verbally and in writing, with adequate time for participants to ask questions.

Following informed consent, a comprehensive psychiatric interview will be completed to identify overall psychiatric diagnoses and symptoms of catatonia. Based on this evaluation, a decision will be made whether or not the individual is testable or untestable for neurocognitive assessments.

A physical exam will be performed which will include weight, height, waist and head circumference, as well as vital signs that include blood pressure
Sponsor: University of Michigan

Current Primary Outcome: Psychiatric, cognitive and biological identification of catatonia in psychiatric illness [ Time Frame: Three months ]

Psychiatric, medical, neuropsychological and biological testing will be completed in approximately 30 subjects and analyzed and reviewed by PI and Co-PIs to determine parameters of catatonia diagnosis in psychiatric patients.


Original Primary Outcome: The proper identification of catatonia in psychiatric illness [ Time Frame: Three months ]

Psychiatric, medical, neuropsychological and biological testing will be completed on subjects and analyzed and reviewed by PI and Co-PIs to determine parameters of catatonia diagnosis in psychiatric patients.


Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Michigan

Dates:
Date Received: October 20, 2016
Date Started: December 2016
Date Completion: October 2020
Last Updated: November 3, 2016
Last Verified: November 2016