Clinical Trial: Pediatric Cardiomyopathy Mutation Analysis

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Pediatric Cardiomyopathy Mutation Analysis

Brief Summary: The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder. This will provide the basis for future genetic counseling as well as contribute to elucidating the biology of normal and abnormal cardiac function.

Detailed Summary: Cardiomyopathy is a genetically heterogeneous heart muscle disorder that results in ventricular dysfunction. While significant progress has been made in identifying the genetic basis of cardiomyopathy in adults, molecular diagnosis in children has proven more challenging and current algorithms do not incorporate mutation analysis in the clinical protocol. However, recent studies indicate that cardiomyopathy outcomes in children are origin specific, highlighting the importance of precise diagnosis. The goal of this study is to identify the genetic causes of pediatric cardiomyopathy. Rapid, comprehensive and cost-effective detection of genetic causes of cardiomyopathy will aid management and development of novel treatment strategies.
Sponsor: Indiana University

Current Primary Outcome: Elucidate the molecular genetics of cardiomyopathy [ Time Frame: 7 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Indiana University

Dates:
Date Received: April 28, 2015
Date Started: April 2014
Date Completion: April 2021
Last Updated: March 7, 2017
Last Verified: March 2017