Clinical Trial: Resistance and Aerobic Exercise for Subclinical Anthracycline Cardiomyopathy
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Resistance and Aerobic Exercise for Subclinical Anthracycline Cardiomyopathy
Brief Summary:
This application proposes a prospective, single arm feasibility clinical trial of a 12-week period of combined endurance and resistance training in survivors of childhood cancer who were treated with doxorubicin and/or daunorubicin and have impaired cardiac function.
Baseline and post intervention imaging, laboratory, and neuropsychological evaluations will be used to determine the effects of the intervention on body composition, serum lipid profile, exercise tolerance, and neurocognitive functioning. Participants will be called weekly to monitor compliance with the intervention. Incentives will be given at intervals during the trial to optimize compliance with the intervention.
Detailed Summary:
This study will evaluate the feasibility of a 12-week exercise intervention on the cardiac function of survivors of childhood cancer treated with anthracyclines and known to have cardiomyopathy.
As a secondary objective, the study will document the effect of a 12-week exercise intervention on exercise tolerance, as determined by measurement of peak VO2 and peak exercise workload, shortening fraction, ejection fraction, and left ventricular wall thickness, and assess the impact of the intervention on neurocognitive functioning in survivors of childhood cancer treated with anthracyclines and known to have cardiomyopathy.
Sponsor: St. Jude Children's Research Hospital
Current Primary Outcome: The primary aim of this proposal is to evaluate the feasibility of a 12-week exercise intervention among survivors of childhood cancer treated with anthracyclines and known to have cardiomyopathy. [ Time Frame: 12 Weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: St. Jude Children's Research Hospital
Dates:
Date Received: February 17, 2010
Date Started: February 2010
Date Completion:
Last Updated: February 6, 2014
Last Verified: February 2014
