Clinical Trial: Use of Nesiritide (BNP) in Kidney Function in Patients With Congestive Heart Failure (CHF) and Kidney Failure

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Efficacy of Intra-renal Infusion of BNP in Enhancing Renal Function in Human CHF With Cardiorenal Syndrome: A Pilot Study

Brief Summary: The objective of this study is to determine the safety and effectiveness of intrarenal administration of brain natriuretic peptide (BNP) in improving renal function as measured by glomerular filtration rate (GFR) and sodium excretion in patients hospitalized with acute congestive heart failure (CHF) and deterioration of kidney function (cardiorenal syndrome).

Detailed Summary:
Sponsor: Horng Chen

Current Primary Outcome: Change in Glomerular Filtration Rate (GFR) at 24 Hours [ Time Frame: baseline, 24 hours after start of infusion ]

Original Primary Outcome: To determine the safety and effectiveness of intrarenal BNP infusion in improving renal function in patients with cardiorenal syndrome

Current Secondary Outcome: Change in Urinary Sodium Excretion at 24 Hours [ Time Frame: baseline, 24 hours after start of infusion ]

Original Secondary Outcome: To determine the neurohumoral effects of intrarenal infusion of BNP in patients with cardiorenal syndrome

Information By: Mayo Clinic

Dates:
Date Received: June 30, 2006
Date Started: December 2005
Date Completion:
Last Updated: September 14, 2012
Last Verified: September 2012