Clinical Trial: Different Genetic Features Associated With Hepatic Carcinogenesis

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Identification of Survival-related microRNAs in Hepatocellular Carcinoma

Brief Summary: The purpose of this study is to identify different genetic features in hepatocellular carcinoma. It will assist in predicting individual risks of disease progression and would help to clarify pathophysiological mechanisms of HCC.

Detailed Summary:

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths in Taiwan. HCC normally develops as a consequence of underlying liver disease and is most often associated with cirrhosis. Surgical resection and liver transplantation are current best curative options to treat HCC. However, recurrence or metastasis is quite common in patients who have had a resection and survival rate is 30% to 40% at 5 years postoperatively.

MicroRNAs, small non-coding RNA, act as endogenous RNA interference by post-transcription regulation. Recent studies suggest that microRNAs may act as tumor suppressors or oncogenes and altered microRNA expression levels may play an important role in the cancer initiation and progression. Several studies, including ourselves, have shown that specific microRNAs are aberrantly expressed in malignant HCC tissues compared to normal counterpart. Although many microRNA profiling studies were done to diagnose hepatocarcinogenesis, data about prognostic significances for postsurgical survival are very limited. The main point of this study is to develop a predictive signature for postsurgical survival in HCC patients.

Sponsor: National Taiwan University Hospital

Current Primary Outcome:

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Information By: National Taiwan University Hospital

Dates:
Date Received: November 22, 2010
Date Started: February 2010
Date Completion: July 2012
Last Updated: November 22, 2010
Last Verified: November 2010