Clinical Trial: Broccoli Sprout Dose Response

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Broccoli Sprout Dose Response

Brief Summary: This study will examine the extent to which lower doses of a broccoli-derived beverage enhance the detoxication of air pollutants excreted in urine as compared to an maximal dose shown to be effective previously.

Detailed Summary: This is a 2-week placebo control Phase II broccoli sprout intervention to be conducted in Qidong, P.R. China. Up to twelve hundred people from the farming townships will be screened and one hundred seventy eligible individuals will be enrolled in the study. Participants will be randomized into 4 treatment groups: one will receive a juice beverage containing a standard dose of glucoraphanin- and sulforaphane-rich broccoli sprout powder mixed in pineapple juice, lime juice and water, the second will receive one-half dose, the third one-fifth dose and the fourth group will receive placebo beverage containing pineapple juice, lime juice and water. Participants will drink their assigned beverage every evening and provide consecutive 12-hour urine collections throughout the duration of the study.
Sponsor: Johns Hopkins Bloomberg School of Public Health

Current Primary Outcome: Sulforaphane Bioavailability Measured in Sequential 12-Hour Urine Samples [ Time Frame: 2 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Modulation of Air Pollutant Excretion in Sequential 12-Hour Urine Samples [ Time Frame: 2 weeks ]

Original Secondary Outcome: Same as current

Information By: Johns Hopkins Bloomberg School of Public Health

Dates:
Date Received: January 5, 2016
Date Started: January 2016
Date Completion:
Last Updated: May 23, 2016
Last Verified: May 2016