Clinical Trial: Carbon Monoxide Blood and DNA Biorepository

Study Status: Enrolling by invitation
Recruit Status: Enrolling by invitation
Study Type: Observational

Official Title: Carbon Monoxide Blood and DNA Repository

Brief Summary: The purpose of this biorepository is to collect blood from patients at the time of CO poisoning and at follow-up visits months to years later. These samples can be used in the future to learn more about how CO damages the heart and brain and whether blood tests could predict which patients will have problems after CO poisoning.

Detailed Summary:

The investigators propose to establish a biorepository for storage of serum, plasma, and DNA collected from patients with carbon monoxide (CO) poisoning. Participants will also be evaluated for clinical outcome. The biorepository will include serum and plasma from CO-poisoned patients drawn at the time of injury as well as from blood drawn at clinical follow-up visits. The biorepository will also bank DNA from these participants.

These specimens can be analyzed in the future to elucidate potential inflammatory and immunological mechanisms that cause brain and heart damage and identify possible biological and genetic predictors of poor outcome.


Sponsor: Intermountain Health Care, Inc.

Current Primary Outcome: Biorepository for serum and plasma [ Time Frame: Within 24 hours of CO Poisoning ]

Serum and plasma from blood collected within 24 hours of acute CO poisoning


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Serum and plasma (sub-acute) [ Time Frame: 4 weeks to 4 months after CO poisoning ]
    Serum and plasma collected 4 weeks to 4 months after poisoning
  • DNA Sequestration [ Time Frame: 24 hours to 12 months after CO poisoning ]
    DNA sequestered from blood drawn up to 1 year from CO poisoning
  • Serum and plasma (long-term) [ Time Frame: 4 months to 12 months after CO poisoning ]
    Serum and plasma collected 4 months to 12 months after poisoning


Original Secondary Outcome: Same as current

Information By: Intermountain Health Care, Inc.

Dates:
Date Received: December 27, 2012
Date Started: February 2012
Date Completion: December 2018
Last Updated: October 4, 2016
Last Verified: October 2016