Clinical Trial: Occult Carbon Monoxide Poisoning Detection by Pulsated Carboxymetry in an Emergency Department
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational
Official Title:
Brief Summary:
In France, the carbon monoxide is one of the first causes of the accidental poisonings with approximately 8000 cases a year, among which 500 deaths.
The severe forms are translated by neurological disorders even a coma or the death straight away. The more insidious forms with a little carboxyhémoglobine level give rise to frustrate clinical pictures, mimicking flu or intestinal syndromes. The syndrome post--intervallaire corresponds to the appearance of remote neuropsychiatric disorders of the poisoning. Its appearance and its gravity are not correlated in the gravity of the initial poisoning, however the precocity of the treatment tends to decrease its frequency.
Carbon monoxide elimination is made under unchanged form in the expired air. In a spontaneous way, the half-life in ambient air is of the order of 4 hours. In ventilation in isobaric pure oxygen, the half-life is shortened at 80 minutes and in hyperbaric oxygen at 23 minutes.
This imposes a fast diagnosis for two reasons:
- For poisonings with low level, the more the investigators wait to measure the carboxyhémoglobine (HBCO), the more they risk not to detect it.
- The oxygen therapy decreases the duration of the poisoning and thus the tissular suffering.
Actually the risk is important to pass next to the diagnosis and to let leave a patient without adapted care and without technical intervention to eliminate the source of the poisoning.
Presently, to make the diagnosis, the investigators possess the analysis of the blood HbCO by realization of gas of the venous blood, which are taken in
Detailed Summary:
Sponsor: Poitiers University Hospital
Current Primary Outcome: Incidence of poisoning carbon monoxide confirmed [ Time Frame: up to 24 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Poitiers University Hospital
Dates:
Date Received: February 19, 2016
Date Started:
Date Completion:
Last Updated: October 12, 2016
Last Verified: October 2016
