Clinical Trial: Treatment of Human Cord Blood Mononuclear Cell for Delayed Encephalopathy After Carbon Monoxide Poisoning

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Treatment of Human Cord Blood Mononuclear Cell for Delayed Encephalopathy After Carbon Monoxide Poisoning

Brief Summary: The effects and safety of Human cord blood mononuclear cell for delayed encephalopathy after carbon monoxide poisoning

Detailed Summary: To evaluate the effect and mechanism of human cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide poisoning
Sponsor: Liaocheng People's Hospital

Current Primary Outcome: Change From Baseline in Mini-Mental State Examination (MMSE) [ Time Frame: Baseline, 4, 8, 12 and 24 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Chang from baseline in head CT [ Time Frame: Baseline, 6 and 12 months ]
  • Cerebrospinal levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1(ng/ul) [ Time Frame: Baseline, 1 and 2 months ]
  • Serum levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1(ng/ul) [ Time Frame: Baseline,1 and 2 months ]
  • Change From Baseline in Activities of Daily Living (ADL) [ Time Frame: Baseline, 4, 8, 12 and 24 weeks ]


Original Secondary Outcome:

  • Chang from baseline in head CT [ Time Frame: Baseline, 6 and 12 months ]
  • Cerebrospinal levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1 [ Time Frame: Baseline, 1 and 2 months ]
  • Serum levels of IL-2,IL-4,IL-6,IL-10,TNF,IFN-γ，IL-17A，IL-8，IL-12p70，MIG，MCP-1 [ Time Frame: Baseline,1 and 2 months ]
  • Change From Baseline in Activities of Daily Living (ADL) [ Time Frame: Baseline, 4, 8, 12 and 24 weeks ]


Information By: Liaocheng People's Hospital

Dates:
Date Received: October 2, 2016
Date Started: October 2016
Date Completion: December 2019
Last Updated: April 17, 2017
Last Verified: April 2017