Clinical Trial: Role of Pulse Co-oximetry for Detecting Carbon Monoxide Poisoning in the Prehospital Emergency Medical Service Setting

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Role of Pulse Co-oximetry in Prehospital Emergency Medical Service Management of Suspected Carbon Monoxide Poisoning : A Prospective Multicenter Study.

Brief Summary:

The RAD-57 pulse CO-oximeter is a lightweight device allowing non-invasive measurement of blood carboxyhemoglobin. Previous studies comparing RAD-57 measurements (SpCO) to standard laboratory blood gas analysis (COHb) have reported contradictory results.

the RAD-57 pulse CO-oximeter could be useful as a first-line screening test for acute CO poisoning, enabling rapid detection and management of patients with suspected CO poisoning in the prehospital emergency setting This study assesses the diagnostic value of pulse CO-oximetry, comparing SpCO to standard laboratory blood measurement for prehospital management of patients with suspected carbon monoxide (CO) poisoning.


Detailed Summary: Transcutaneous SpCO will be obtained using the RAD-57 simultaneously with blood sampling for laboratory blood gas analysis, at the time of prehospital management by emergency medical services. The diagnostic performance of SpCO for the screening of CO poisoning will be determined using ROC curve analysis, and Blood COHb levels >5% and 10% as the reference standard for CO poisonning for non-smokers and smokers respectively. Correlation between SpCO and COHb will be assessed using Bland and Altman's method.
Sponsor: University Hospital, Montpellier

Current Primary Outcome: SpCO optimal threshold value for detection of CO poisoning [ Time Frame: Baseline ]

prehospital medical management


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • SpCO level [ Time Frame: Baseline ]
    prehospital medical management
  • COHb Blood carboxyhemoglobin level [ Time Frame: Baseline ]
    prehospital medical management


Original Secondary Outcome: Same as current

Information By: University Hospital, Montpellier

Dates:
Date Received: August 2, 2016
Date Started: February 2012
Date Completion: December 2017
Last Updated: August 8, 2016
Last Verified: August 2016