Clinical Trial: Measuring the Glycemic Index of Pulse Based Breads

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Measuring the Glycemic Index of Pulse Based Breads

Brief Summary: The objective of this study is to determine the glycemic index of 4 pulse-based breads in at least 10 normal healthy human volunteers. Participants will be studied in the morning on 6 separate days after overnight fasts. On the first and last days they will consume a test meal consisting of about 2 slices of white bread (50g carbohydrate) and on the other 4 days they will consume 2-3 slices (50g carbohydrate) from 4 different test breads containing starch obtained from pulses (beans and/or lentils). Blood glucose will be measured at intervals over 2 hours. Glycemic index is calculated as 0.71 times F/WB where F is the incremental area under the curve of blood glucose (AUC) after each test bread and WB is the mean AUC after white bread.

Detailed Summary:
Sponsor: Glycemic Index Laboratories, Inc

Current Primary Outcome: Glycemic Index [ Time Frame: 120 minutes ]

Glycemic index is 0.71 times F/WB where F is the incremental area under the blood glucose response curve ignoring area below fasting (AUC) elicited by a pulse bread, and WB is the mean AUC elicited by White Bread. AUC is calculated using the trapezoid rule from 2 measures of fasting blood glucose taken 5 minutes apart (the average of these measures is taken to be fasting blood glucose) and measures of blood glucose at 15, 30, 45, 60, 90 and 120 minutes after starting to eat. The mean of the values for each pulse bread in each subject is the glycemic index.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Incremental area under the blood glucose response curve [ Time Frame: 120 minutes ]
    Incremental area under the blood glucose response curve ignoring area below fasting (AUC) is calculated using the trapezoid rule from 2 measures of fasting blood glucose taken about 5 minutes apart (the average of these measures is taken to be fasting blood glucose) and measures of blood glucose at 15, 30, 45, 60, 90 and 120 minutes after starting to eat.
  • Peak blood glucose concentration (Cmax) [ Time Frame: 120 minutes ]
    Cmax is the maximum of the blood glucose concentrations measured at 15, 30, 45, 60, 90 and 120 minutes after consumption of a test meal.
  • Peak rise of blood glucose [ Time Frame: 120 minutes ]
    The maximum of the blood glucose concentrations measured at 15, 30, 45, 60, 90 and 120 minutes after consumption of a test meal minus the fasting blood glucose concentration.


Original Secondary Outcome: Same as current

Information By: Glycemic Index Laboratories, Inc

Dates:
Date Received: January 6, 2017
Date Started: January 2017
Date Completion:
Last Updated: April 26, 2017
Last Verified: January 2017