Clinical Trial: Candidemia in a Pediatric Center and Importance of Central Venous Catheter Removal

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title:

Brief Summary: Candidemia has emerged as an important cause of hospital-associated blood-stream infection in children. The purpose of this study was to identify differences in distribution of candida species, risk factors, treatment, and clinical outcome of candidemia in children. This study in children ≤18 years with blood culture proven candidemia identified between 2004 and 2012. Analyses included the determination of causative candida species, resistance to antifungals and clinical outcome, as well as the identification of potential risk factors associated with candidemia.

Detailed Summary:
Sponsor: Hacettepe University

Current Primary Outcome: Risk factors of candidemia [ Time Frame: up to 3 months ]

The presence or absence of potential risk factors for candidemia such as an indwelling central venous catheter (CVC), use of antibiotics (administered for >72 hours), use of antifungals (administered for >24 hours), immunosuppressants, total parenteral nutrition (TPN), admission to the intensive care unit (ICU), mechanical ventilation, neutropenia, hypoalbuminemia and hypophosphatemia.


Original Primary Outcome: Same as current

Current Secondary Outcome: Prognosis according to candida species [ Time Frame: up to 3 months ]

Death which ensues within 30 days of the onset of candidemia with no apparent alternative cause is recognized as a candidemia-attributable mortality. Patients who died and survived were compared according to candida species (C.albicans, C. parapsilosis, C. tropicalis, C. sake, C.glabrata).


Original Secondary Outcome: Same as current

Information By: Hacettepe University

Dates:
Date Received: March 10, 2014
Date Started: January 2004
Date Completion:
Last Updated: March 14, 2014
Last Verified: March 2014