Clinical Trial: Efficacy of Interferon-gamma in Combination With Anidulafungin for the Treatment of Candidemia
Study Status: Terminated
Recruit Status: Unknown status
Study Type: Interventional
Official Title: A Multicentre, Prospective, Randomized Open-label Pilot Study to Assess the Feasibility and Preliminary Efficacy of Interferon-gamma in Combination With Anidulafungin for the Treatment of
Brief Summary: The purpose of this study is to assess the feasibility and preliminary efficacy of interferon-gamma in combination with anidulafungin for the treatment of candidemia
Detailed Summary:
Sponsor: Radboud University
Current Primary Outcome: the time to negative blood cultures [ Time Frame: at fixed time points during follow up (at least until 8 weeks after end of treatment) ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- overall survival [ Time Frame: until 8 weeks after end of treatment ]
- time to death [ Time Frame: Until 8 weeks after end of treatment ]
- outcome of fungal infection [ Time Frame: Until 8 weeks after end of treatment ]resolution at week 2 and 8 after end of treatment, patient status at end of therapy, microbiological parameters
- duration of antifungal therapy [ Time Frame: Until end of treatment ]
- duration of hospitalization [ Time Frame: Until end of hospitilization ]
- immunological parameters [ Time Frame: Until 8 weeks after end of treatment ]
- tolerability and safety [ Time Frame: until 8 weeks after end of treatment ]
Original Secondary Outcome: Same as current
Information By: Radboud University
Dates:
Date Received: January 4, 2011
Date Started: January 2011
Date Completion:
Last Updated: February 13, 2012
Last Verified: February 2012