Clinical Trial: Importance of Peritoneal Free Fluid Cultures in Acute Appendicitis

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Observational

Official Title: Importance of Peritoneal Free Fluid Cultures in Both Perforated and Non-perforated Appendicitis

Brief Summary: The purpose of this study is to evaluate the frequency of positive free fluid cultures in both perforated and non-perforated appendicitis. In addition predictors of positive free fluid cultures will be analyzed.

Detailed Summary:

Prior to surgery, all patients will receive antibioprophylaxis. In case of free peritoneal fluid, a sample is aspirated and sent for microbiology. A lavage with saline is not necessary. The decision to start postoperative antibiotic is left at the discretion of the surgeon. The decision to leave an abdominal drain is left at the discretion of the surgeon.

The use of a preoperative single dose administration of antibiotics has been extensively studied and found beneficial in the prevention of SSI in appendicitis. However, the use of continued postoperative antibiotics has barely been studied. The sparse evidence that exist does not seem to support its systematic use. During appendectomy the surgeon frequently encounters turbid free fluid, even in non-perforated appendicitis. It is common practice in Belgium to continue antibiotic prophylaxis for 5 days after aspiration and lavage. Although the aspect often seems purulent, it is unknown in what percentage this fluid is contaminated. Also, it is unknown whether after aspiration and lavage intra-abdominal drains are necessary.

Sponsor: Universitaire Ziekenhuizen Leuven

Current Primary Outcome: To evaluate the frequency of positive free fluid cultures in both perforated and non-perforated appendicitis [ Time Frame: 24 hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Universitaire Ziekenhuizen Leuven

Dates:
Date Received: February 19, 2013
Date Started: July 2012
Date Completion:
Last Updated: July 3, 2015
Last Verified: July 2015