Clinical Trial: Hemodialysis Frequency and the Calcification Propensity of Serum
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Hemodialysis Frequency and the Calcification Propensity of Serum
Brief Summary: The aim of this clinical research project is to test the hypothesis that daily dialysis has favorable effects on the calcification propensity of human serum, when determined by the investigators' newly developed in vitro serum test. The investigators' hypothesis is that shorter interdialytic intervals will result in an improved calcification propensity of serum. The determination of serum calcification has the potential to become a novel measure of dialysis quality in the future.
Detailed Summary:
Background
The serum calcification test has been established and validated by A. Pasch and coworkers, the expertise to perform the necessary statistical analyses is present in the investigator's department, all patient-related procedures necessary for this project are routinely performed in the investigator's department.
Objective
Does short daily hemodialysis strengthen the calcification-inhibitory forces inherent in hemodialysis patient sera, when compared to conventional three-times weekly hemodialysis?
Methods
Serum calcification test
Sponsor: University Hospital Inselspital, Berne
Current Primary Outcome: Change from baseline calcification propensity of serum [ Time Frame: 6 weeks ]
Original Primary Outcome: Change from baseline in concentration of calcification in serum [ Time Frame: 6 weeks ]
Current Secondary Outcome: Change from baseline of sodium, potassium, calcium, phosphate, magnesium, albumin, protein, hematocrit and their correlation with calcification propensity of serum [ Time Frame: 6 weeks ]
Original Secondary Outcome: Change from baseline in calcification propensity of serum [ Time Frame: 6 weeks ]
Information By: University Hospital Inselspital, Berne
Dates:
Date Received: October 25, 2013
Date Started: June 2014
Date Completion:
Last Updated: April 5, 2016
Last Verified: April 2016
