Clinical Trial: Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Computerized Working Memory Training in Adults With Substance Abuse and Executive Function Deficits: A Randomised Controlled Trial.

Brief Summary: The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse and attention problems.

Detailed Summary: The primary aim of this study is to examine the effects of 5 weeks of computerized working memory training on substance abuse. Secondary aims are to explore whether effects are mediated by changes in executive functions and/or moderated by personality. Also, effects on measures of psychosocial functioning, depression, anxiety and attention will be explored. Follow-up assessment will be conducted at 6 months post training.
Sponsor: Örebro Läns Landsting

Current Primary Outcome: Change from baseline in substance abuse measured with Substance abuse scales in Adult Self Report (ASR; ASEBA). [ Time Frame: Baseline and at 25 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change from baseline in Adult Self Report (ASR; ASEBA) Attention problems scale. [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in Adult Self Report (ASR; ASEBA) Internalizing index. [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in Adult Self Report (ASR; ASEBA) Externalizing index. [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in Adult Self Report (ASR; ASEBA) Adaptive functioning scales. [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in Executive functioning measured with Behavior Rating Inventory of Executive Function-Adult (BRIEF-A). [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in verbal working memory measured with performance on Digit span. [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in visual working memory measured with performance on Span board. [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in focused attention measured with performance on Conners Continuous Performance Test-II (CCPT-II). [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in vigilance measured with performance on Conners Continuous Performance Test-II (CCPT-II). [ Time Frame: Baseline and at 25 weeks ]
  • Change from baseline in reading speed measured with performance on Reading speed in Diagnostic Reading and Writing Test (DLS; Swedish version). [ Time Frame: Baseline and at 25 weeks ]


Original Secondary Outcome: Same as current

Information By: Örebro Läns Landsting

Dates:
Date Received: February 19, 2014
Date Started: January 2014
Date Completion: December 2016
Last Updated: October 22, 2015
Last Verified: October 2015