Clinical Trial: Angina in Non Coronary Artery Disease

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Invasive Findings in Patients With Angina Equivalent Symptoms But No Coronary Artery Disease; Results From the Heart Quest Cohort Study

Brief Summary: Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia. The aim of this study is to systematically assess patients with angina equivalent symptoms despite normal coronary angiograms and to evaluate their symptoms according to a defined algorithm.

Detailed Summary: All consecutive patients who had coronary angiography at the Luzerner Kantonsspital between July 1st 1996 and July 31st 2008 and who had no significant coronary stenoses (no coronary stenoses ≥ 50%) were recruited for this study. Patients are extensively examined during angiography using acetylcholine infusion and fast atrial pacing. According to the result of the additional invasive examination (vasospasm, vasoconstriction, vasodilation; symptoms during examination) a distinct diagnosis is attributed to the patients (small vessel disease, vasospastic disease, hypertensive heart disease, rhythm disorder, or extracardiac thoracic pain including pulmonary hypertension). Patients are followed-up after 10 years and prognosis of these patients is assessed (including mortality, cardiovascular events, re-angiography, functional status after 10 years).
Sponsor: Luzerner Kantonsspital

Current Primary Outcome:

  • Cause of angina equivalent symptoms in patients with no coronary artery disease [ Time Frame: One day ]
  • Prognosis of patients with angina equivalent symptoms and normal coronary arteries [ Time Frame: 10 years after baseline assessment ]


Original Primary Outcome:

  • Cause of angina equivalent symptoms in patients with no coronary artery disease [ Time Frame: At baseline during coronary angiography ]
  • Prognosis of patients with angina equivalent symptoms and normal coronary arteries [ Time Frame: 10 years after baseline assessment ]


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Luzerner Kantonsspital

Dates:
Date Received: March 17, 2011
Date Started: July 1996
Date Completion: July 2018
Last Updated: April 16, 2013
Last Verified: April 2013