Clinical Trial: Multidetector Coronary CT In Vasospastic Angina

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Diagnostic Usefulness of Multidetector Coronary CT in Vasospastic Angina

Brief Summary: The purpose of this study is to compare the extent of coronary vessel stenosis between coronary spasm-induced angina attacks (named vasospastic angina, VSA) patients and health volunteers by multi-detector computed tomography angiography (MDCTA), and to evaluate the diagnostic efficacy of MDCTA in patients with VSA.

Detailed Summary:

Vasospastic angina (VSA) was characterized by transient ischemic ST-segment change during angina attacks. Coronary spasm provocation test, as a diagnostic golden standard, has been widely used for the management of VSA according to JCS 2013 guidelines.

With regard to the characteristics of spasm segment, had been clearly described by other invasive imaging methods including intravascular ultrasound and optical coherence tomography. However, there is potential risk during these invasive procedures, such as severe myocardial ischemia or fatal arrhythmia.

Presently available imaging test for coronary artery disease including multi-detector computed tomography angiography (MDCTA) with high diagnostic accuracy to evaluate coronary artery stenosis. However, the diagnostic accuracy of MDCTA in patients with VSA is lacking.

Therefore, more efficient and safe noninvasive diagnostic method is required for the detection of angina-like attacks patients.


Sponsor: Dong-A University

Current Primary Outcome: Characteristics of coronary lesion [ Time Frame: CAG will be performed after multidetector coronary CT, an expected average of 4 weeks. ]

  1. Plaque composition: noncalcified plaque, which is < 130 Hounsfield units(HU). Calcified plaque with a density of > 130 HU. Mixed plaque: plaque area consisted of > 50% of non-calcified plaque.
  2. The remodeling index (RI) was calculated by dividing the cross-sectional lesion vessel-area by the reference vessel area.Positive remodeling was defined as RI > 1.05, otherwise RI ≤0.95.
  3. Significant stenosis is defined as stenosis in more than 50% of the coronary artery diameter.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Dong-A University

Dates:
Date Received: June 29, 2014
Date Started: April 2014
Date Completion: January 2018
Last Updated: October 25, 2016
Last Verified: October 2016