Clinical Trial: Efficacy Study of Atorvastatin to Treat Variant Angina

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Efficacy Study of Atorvastatin to Treat Variant Angina

Brief Summary: The objective of this study is to evaluate effect of statin treatment for vasospastic angina.

Detailed Summary:

Vasospastic angina is presented by myocardial ischemia with spasm of coronary artery accompanying chest pain or discomfort. The precise mechanisms have not been established, but a reduction in NO (nitric oxide) production, an imbalance between endothelium-derived relaxing and contracting factors,or an injury of endothelium have been suggested.

Impaired FMD(flow mediated endothelium-dependent vasodilation) in the brachial artery was demonstrated in vasospastic angina,and improvement of endothelial dysfunction with treatment of statin is documented in several studies.

So, we expect that statin treatment for vasospastic angina provide additional therapeutic effects via improvement of endothelial dysfunction.

Sponsor: Samsung Medical Center

Current Primary Outcome: Ergonovine provocation test 24hrs later after admission [ Time Frame: 1 year later ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Chest pain with EKG change during admission for 24hrs at 12mo. later (All medications are withheld for 48hrs. before admission) [ Time Frame: 1year later ]

Original Secondary Outcome: Same as current

Information By: Samsung Medical Center

Dates:
Date Received: February 10, 2008
Date Started: January 2008
Date Completion: December 2010
Last Updated: April 2, 2009
Last Verified: April 2009